Next-Generation Sequencing-Based Clonality Assessment of Ig Gene Rearrangements: A Multicenter Validation Study by EuroClonality-NGS.

doi:10.1016/j.jmoldx.2021.06.005

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Next-Generation Sequencing-Based Clonality Assessment of Ig Gene Rearrangements: A Multicenter Validation Study by EuroClonality-NGS.

The Journal of molecular diagnostics : JMD - 1 Sept 2021

van den Brand Michiel, Rijntjes Jos, Möbs Markus, Steinhilber Julia, van der Klift Michèle Y, Heezen Kim C, Kroeze Leonie I, Reigl Tomas, Porc Jakub, Darzentas Nikos, Luijks Jeroen A C W, Scheijen Blanca, Davi Frédéric, ElDaly Hesham, Liu Hongxiang, Anagnostopoulos Ioannis, Hummel Michael, Fend Falko, Langerak Anton W, Groenen Patricia J T A

Abstract excerpt

Ig gene (IG) clonality analysis has an important role in the distinction of benign and malignant B-cell lymphoid proliferations and is mostly performed with the conventional EuroClonality/BIOMED-2 multiplex PCR protocol and GeneScan fragment size analysis. Recently, the EuroClonality-NGS Working Group developed a method for next-generation sequencing (NGS)-based IG clonality analysis. Herein, we report the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Data Accuracy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Genes, Immunoglobulin

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin kappa-Chains

Share to Lymphoma, B-Cell

Share to Lymphoma, Follicular

Share to Multiplex Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 34186174
DOI: 10.1016/j.jmoldx.2021.06.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Next-Generation Sequencing-Based Clonality Assessment of Ig Gene Rearrangements: A Multicenter Validation Study by EuroClonality-NGS.PMID 34186174Read ↗

Next-generation sequencing of immunoglobulin gene rearrangements for clonality assessment: a technical feasibility study by EuroClonality-NGSSemantic proximity Read ↗

Clonality assessment and detection of clonal diversity in classic Hodgkin lymphoma by next-generation sequencing of immunoglobulin gene rearrangementsSemantic proximity Read ↗

Validation of the EuroClonality-NGS DNA capture panel as an integrated genomic tool for lymphoproliferative disorders.Semantic proximity Read ↗

EuroClonality-NGS Recommendations for Evaluation of B-Cell Clonality Analysis by Next-Generation SequencingSemantic proximity Read ↗

The evolution of clonality testing in the diagnosis and monitoring of hematological malignanciesSemantic proximity Read ↗

Establishment of Immunoglobulin Heavy (IGH) Chain Clonality Testing by Next-Generation Sequencing for Routine Characterization of B-Cell and Plasma Cell NeoplasmsSemantic proximity Read ↗

Multiple Immunoglobulin κ Gene Rearrangements within a Single Clone Unraveled by Next-Generation Sequencing-Based Clonality Assessment.Semantic proximity Read ↗

A Comparison of Deep Sequencing of <i>TCRG</i> Rearrangements vs Traditional Capillary Electrophoresis for Assessment of Clonality in T-Cell Lymphoproliferative DisordersSemantic proximity Read ↗

Clonality testing of malignant lymphomas with the BIOMED-2 primers in a large cohort of 1969 primary and consultant biopsies.Semantic proximity Read ↗

Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936.Semantic proximity Read ↗

CloneRetriever: An Automated Algorithm to Identify Clonal B and T Cell Gene Rearrangements by Next-Generation Sequencing for the Diagnosis of Lymphoid MalignanciesSemantic proximity Read ↗

T cell clonality assessment: past, present and futureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.