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Article

Diffuse large B-cell lymphomas of immunoblastic type are a major reservoir for MYC-IGH translocations.

The American journal of surgical pathology - 1 Jan 2015

Horn Heike, Staiger Annette M, Vöhringer Matthias, Hay Ulrich, Campo Elias, Rosenwald Andreas, Ott German, Ott M Michaela

Abstract excerpt

The immunoblastic variant of diffuse large B-cell lymphoma (IB-DLBCL) has recently been recognized as an aggressive lymphoma type with inferior prognosis as compared with other DLBCL variants. At the same time, the presence of MYC rearrangements in DLBCL has been shown to indicate shorter survival in R-CHOP-treated patients. In this study, we investigated the occurrence of MYC gene rearrangements in IB-DLBCL...

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Share to Biopsy
Share to Genes, Immunoglobulin Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

Share to Lymphoma, Large B-Cell, Diffuse

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Share to Proto-Oncogene Proteins c-myc

Share to Translocation, Genetic

Source

Identifiers

PMID: 25229766
DOI: 10.1097/PAS.0000000000000319

Genes

MYC
IGH
BCL2
BCL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Diffuse large B-cell lymphomas of immunoblastic type are a major reservoir for MYC-IGH translocations.PMID 25229766Read ↗

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