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Article

ZP2 peptide beads select human sperm in vitro, decoy mouse sperm in vivo, and provide reversible contraception

27 Apr 2016

Abstract excerpt

Gamete recognition in the female reproductive tract occurs at the surface of the zona pellucida surrounding ovulated eggs. The acellular zona matrix is composed of three (mouse) or four (human) proteins (ZP1 to ZP4), and the amino terminus of ZP2 is the primary sperm-binding ligand. Mouse and human sperm bind, respectively, to recombinant moZP2(35-149) and huZP2(39-154) peptides attached to agarose beads. Mouse...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 27122613
DOI: 10.1126/scitranslmed.aad9946

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