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Article

A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans

16 Jun 2014

Abstract excerpt

The extracellular zona pellucida surrounds ovulated eggs and mediates gamete recognition that is essential for mammalian fertilization. Zonae matrices contain three (mouse) or four (human) glycoproteins (ZP1-4), but which protein binds sperm remains controversial. A defining characteristic of an essential zona ligand is sterility after genetic ablation. We have established transgenic mice expressing human ZP4...

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PMID: 24934154
DOI: 10.1083/jcb.201404025

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