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Article

The molecular basis of gamete recognition in mice and humans

17 Jan 2013

Abstract excerpt

Successful fertilization heralds the onset of development and requires both gamete recognition and a definitive block to polyspermy. Sperm initially bind and penetrate the extracellular zona pellucida (ZP) that surrounds ovulated eggs, but are unable to bind the zona surrounding preimplantation embryos. The ZP of humans is composed of four (ZP1-4) and that of mouse three (ZP1-3) glycoproteins. Models for gamete...

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PMID: 23335731
DOI: 10.1093/molehr/gat004

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