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Article

Functional heterogeneity of sperm binding to the ZP2 N terminus across normospermic and infertile phenotypes.

Journal of translational medicine - 9 May 2026

Ata Manar, Abdulla Maha A, Choucair Fadi, Hamada Dania, Esteves Maria Sousa, Ali Fatima Al, Garibova Suma, Sathappan Abbirami, Awwad Johnny T, Avella Matteo A

Abstract excerpt

BACKGROUND: Human gamete recognition is mediated by the N-terminal domain of the zona pellucida protein ZP2. Conventional semen analysis often fails to identify functional subpopulations within heterogeneous ejaculates, particularly in men with defective spermiogenesis. This study sought to evaluate if a recombinant ZP239-154 peptide can serve as a high-stringency selection tool to identify and enrich for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42106809
DOI: 10.1186/s12967-026-08228-5
PMCID: PMC13330299

Genes

ZP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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