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Reassessing the molecular biology of sperm–egg recognition with mouse genetics

19 Dec 2003

Abstract excerpt

The zona pellucida is an extracellular coat that surrounds mammalian eggs and early embryos. This insoluble matrix separates germ from somatic cells during folliculogenesis and plays critical roles during fertilization and early development. The mouse and human zona pellucida contain three glycoproteins (ZP1 or ZPB, ZP2, ZP3), the primary structures of which have been deduced by molecular cloning. Targeted...

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PMID: 14696038
DOI: 10.1002/bies.10412

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