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Article

Gamete Recognition in Mice Depends on the Cleavage Status of an Egg’s Zona Pellucida Protein

8 Jul 2010

Abstract excerpt

At fertilization, mouse sperm bind to the zona pellucida (which consists of glycoproteins ZP1, ZP2, and ZP3) that surrounds eggs. A ZP2 cleavage model of gamete recognition requires intact ZP2, and a glycan release model postulates that zona glycans are ligands for sperm. These two models were tested by replacing endogenous protein with ZP2 that cannot be cleaved (Zp2(Mut)) or with ZP3 lacking implicated O...

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PMID: 20616279
DOI: 10.1126/science.1188178

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