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Article

Zona pellucida glycoprotein ZP3 and fertilization in mammals

5 Jun 2009

Abstract excerpt

An early step in mammalian fertilization is species-restricted binding of sperm to the egg's zona pellucida (ZP), a thick extracellular coat that surrounds eggs. Sperm bind to the ZP of unfertilized eggs, but not to the ZP of fertilized eggs. Shortly after binding to the unfertilized egg ZP, sperm undergo the acrosome reaction, a form of cellular exocytosis that enables sperm to penetrate the ZP. Three...

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PMID: 19504560
DOI: 10.1002/mrd.21046

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