Article
The first intracellular loop of GLUT4 contains a retention motif.
Journal of cell science - 1 Jun 2016
Talantikite Maya, Berenguer Marion, Gonzalez Teresa, Alessi Marie Christine, Poggi Marjorie, Peiretti Franck, Govers Roland
Abstract excerpt
Glucose transporter GLUT4 (also known as SLC2A4) plays a major role in glucose homeostasis and is efficiently retained intracellularly in adipocytes and myocytes. To simplify the analysis of its retention, here, various intracellular GLUT4 domains were fused individually to reporter molecules. Of the four short cytoplasmic loops of GLUT4, only the first nine-residue-long loop conferred intracellular retention of...
Topics
- 3T3-L1 Cells
- Adipocytes
- Amino Acid Motifs
- Animals
- CD4 Antigens
- DNA Mutational Analysis
- Genes, Reporter
- Glucose Transporter Type 4
- Insulin
- Intracellular Space
- Mice
- Mutation
- Protein Domains
- Protein Structure, Secondary