GLUT-4 NH2 terminus contains a phenylalanine-based targeting motif that regulates intracellular sequestration.

doi:10.1083/jcb.121.6.1221

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Article

GLUT-4 NH2 terminus contains a phenylalanine-based targeting motif that regulates intracellular sequestration.

The Journal of cell biology - 1 Jun 1993

Piper R C, Tai C, Kulesza P, Pang S, Warnock D, Baenziger J, Slot J W, Geuze H J, Puri C, James D E

Abstract excerpt

Expression of chimeras, composed of portions of two different glucose transporter isoforms (GLUT-1 and GLUT-4), in CHO cells had indicated that the cytoplasmic NH2 terminus of GLUT-4 contains important targeting information that mediates intracellular sequestration of this isoform (Piper, R. C.,...

Topics

Amino Acid Sequence
Animals
Biological Transport
CHO Cells
Clathrin
Cricetinae
Deoxyglucose
Glucose Transporter Type 4
Molecular Sequence Data
Monosaccharide Transport Proteins
Muscle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Phenylalanine

Protein Sorting Signals

Sequence Deletion

Structure-Activity Relationship

Subcellular Fractions

Source

Open in PubMed Open full text

Identifiers

PMID: 8509445
DOI: 10.1083/jcb.121.6.1221
PMCID: PMC2119717

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8509445-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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