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Article

Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Apr 2016

Rainey Robert N, Ng Sum-Yan, Llamas Juan, van der Horst Gijsbertus T J, Segil Neil

Abstract excerpt

UNLABELLED: Cisplatin is a common and effective chemotherapeutic agent, yet it often causes permanent hearing loss as a result of sensory hair cell death. The causes of sensitivity to DNA-damaging agents in nondividing cell populations, such as cochlear hair and supporting cells, are poorly understood, as are the specific DNA repair pathways that protect these cells. Nucleotide excision repair (NER) is a...

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Identifiers

PMID: 27122034
DOI: 10.1523/JNEUROSCI.3890-15.2016
PMCID: PMC4846672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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