Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Mar 2015

Nagtegaal A Paul, Rainey Robert N, van der Pluijm Ingrid, Brandt Renata M C, van der Horst Gijsbertus T J, Borst J Gerard G, Segil Neil

Abstract excerpt

Sensory hair cells in the cochlea, like most neuronal populations that are postmitotic, terminally differentiated, and non-regenerating, depend on robust mechanisms of self-renewal for lifelong survival. We report that hair cell homeostasis requires a specific sub-branch of the DNA damage nucleotide excision repair pathway, termed transcription-coupled repair (TCR). Cockayne syndrome (CS), caused by defects in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acoustic Stimulation
Share to Cochlea

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evoked Potentials, Auditory, Brain Stem

Share to Hair Cells, Auditory, Inner

Share to Hearing Loss

Share to Nerve Degeneration

Share to Otoacoustic Emissions, Spontaneous

Share to Poly-ADP-Ribose Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25762674
DOI: 10.1523/JNEUROSCI.5063-14.2015
PMCID: PMC4355199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cockayne syndrome group B (Csb) and group a (Csa) deficiencies predispose to hearing loss and cochlear hair cell degeneration in mice.PMID 25762674Read ↗

Mutations in Cockayne Syndrome-Associated Genes (Csa and Csb) Predispose to Cisplatin-Induced Hearing Loss in Mice.Semantic proximity Read ↗

UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.Semantic proximity Read ↗

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.Semantic proximity Read ↗

Different Effects ofCSAandCSBDeficiency on Sensitivity to Oxidative DNA DamageSemantic proximity Read ↗

Disorders of nucleotide excision repair.Semantic proximity Read ↗

Cockayne syndrome pathogenesis: lessons from mouse models.Semantic proximity Read ↗

Repair of oxidatively generated DNA damage in Cockayne syndrome.Semantic proximity Read ↗

Increased apoptosis, p53 up-regulation, and cerebellar neuronal degeneration in repair-deficient Cockayne syndrome miceSemantic proximity Read ↗

Cockayne syndrome: the expanding clinical and mutational spectrum.Semantic proximity Read ↗

Congenital DNA repair deficiency results in protection against renal ischemia reperfusion injury in mice.Semantic proximity Read ↗

Dysmyelination not demyelination causes neurological symptoms in preweaned mice in a murine model of Cockayne syndrome.Semantic proximity Read ↗

Role of Cockayne Syndrome B (CSB) Protein in Genome Maintenance in Human Cells under Oxidative StressSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.