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Article

Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype.

Oncotarget - 2 Aug 2016

Deevi Ravi K, McClements Jane, McCloskey Karen D, Fatehullah Aliya, Tkocz Dorota, Javadi Arman, Higginson Robyn, Marsh Durban Victoria, Jansen Marnix, Clarke Alan, Loughrey Maurice B, Campbell Frederick C

Abstract excerpt

Development of cribriform morphology (CM) heralds malignant change in human colon but lack of mechanistic understanding hampers preventive therapy. This study investigated CM pathobiology in three-dimensional (3D) Caco-2 culture models of colorectal glandular architecture, assessed translational relevance and tested effects of 1,25(OH)2D3,theactive form of vitamin D. CM evolution was driven by oncogenic...

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Identifiers

PMID: 27119498
DOI: 10.18632/oncotarget.8863
PMCID: PMC5226489

Genes

PTEN
PRKCZ
CDC42
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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