Article
Intestinal Cell Differentiation and Phenotype in 2D and 3D Cell Culture Models.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023
Martínez-Espuga Magda, Mata Alvaro, Ordóñez-Morán Paloma
Abstract excerpt
Three-dimensional (3D) culture models are more physiologically relevant than two-dimensional (2D) cell culture models. 2D approaches cannot reproduce the complexity of the tumor microenvironment and are less able to translate biological insights; and drug response studies have many limitations to be extrapolated to the clinics. Here, we use the Caco-2 colon cancer cell line, which is an immortalized human...
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