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Placental Hypomethylation Is More Pronounced in Genomic Loci Devoid of Retroelements

1 Jul 2016

Abstract excerpt

The human placenta is hypomethylated compared to somatic tissues. However, the degree and specificity of placental hypomethylation across the genome is unclear. We assessed genome-wide methylation of the human placenta and compared it to that of the neutrophil, a representative homogeneous somatic cell. We observed global hypomethylation in placenta (relative reduction of 22%) compared to neutrophils. Placental...

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Share to Epigenetics and DNA Methylation
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PMID: 27172225
DOI: 10.1534/g3.116.030379

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