Article
A CT60G>A polymorphism in the CTLA-4 gene of the recipient may confer susceptibility to acute graft versus host disease after allogeneic hematopoietic stem cell transplantation.
Immunogenetics - 1 Jun 2015
Karabon Lidia, Markiewicz Miroslaw, Partyka Anna, Pawlak-Adamska Edyta, Tomkiewicz Anna, Dzierzak-Mietla Monika, Kyrcz-Krzemien Slawomira, Frydecka Irena
Abstract excerpt
T cell activation plays a crucial role in the development of acute graft versus host disease (aGvHD). Cytotoxic T cell antigen-4 (CTLA-4) is a co-inhibitory molecule that negatively regulates T cell activation, differentiation, and proliferation. Single-nucleotide polymorphisms (SNPs) in CTLA-4 gene may affect its function. Inconsistent observations have been reported regarding the associations of CTLA-4 SNPs...
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