Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors.

doi:10.1016/j.bbmt.2011.05.021

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Article

Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jan 2012

Bosch-Vizcaya Anna, Pérez-García Arianne, Brunet Salut, Solano Carlos, Buño Ismael, Guillem Vicent, Martínez-Laperche Carolina, Sanz Guillermo, Barrenetxea Cristina, Martínez Carmen, Tuset Esperanza, Lloveras Natàlia, Coll Rosa, Guardia Ramon, González Yolanda, Roncero Josep M, Bustins Anna, Gardella Santiago, Fernández Cristalina, Buch Joan, Gallardo David

Abstract excerpt

CTLA-4 (cytotoxic T-lymphocyte antigen-4) plays a pivotal role in inhibiting T cell activation through competitive interaction with B7 molecules and interruption of costimulatory signals mediated by CD28. Polymorphisms on the CTLA-4 gene have been previously associated with autoimmune diseases, predisposition to leukemic relapse, and with graft-versus-host disease (GVHD) or relapse after allogeneic transplant. As...

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PMID: 21703972
DOI: 10.1016/j.bbmt.2011.05.021

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