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Article

Characterization of Drosophila CMP-sialic acid synthetase activity reveals unusual enzymatic properties.

The Biochemical journal - 1 Jul 2016

Mertsalov Ilya B, Novikov Boris N, Scott Hilary, Dangott Lawrence, Panin Vladislav M

Abstract excerpt

CMP-sialic acid synthetase (CSAS) is a key enzyme of the sialylation pathway. CSAS produces the activated sugar donor, CMP-sialic acid, which serves as a substrate for sialyltransferases to modify glycan termini with sialic acid. Unlike other animal CSASs that normally localize in the nucleus, Drosophila melanogaster CSAS (DmCSAS) localizes in the cell secretory compartment, predominantly in the Golgi, which...

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Identifiers

PMID: 27114558
DOI: 10.1042/BCJ20160347
PMCID: PMC5086458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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