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Article

Structural Analysis of Mammalian Sialic Acid Esterase.

Journal of molecular biology - 15 Nov 2024

Ide Danilo, Gorelik Alexei, Illes Katalin, Nagar Bhushan

Abstract excerpt

Sialic acid esterase (SIAE) catalyzes the removal of O-acetyl groups from sialic acids found on cell surface glycoproteins to regulate cellular processes such as B cell receptor signalling and apoptosis. Loss-of-function mutations in SIAE are associated with several common autoimmune diseases including Crohn's, ulcerative colitis, and arthritis. To gain a better understanding of the function and regulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39321866
DOI: 10.1016/j.jmb.2024.168801

Genes

SIAE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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