Article
Deficits in sialylation impair podocyte maturation.
Journal of the American Society of Nephrology : JASN - 1 Aug 2012
Weinhold Birgit, Sellmeier Melanie, Schaper Wiebke, Blume Linda, Philippens Brigitte, Kats Elina, Bernard Ulrike, Galuska Sebastian P, Geyer Hildegard, Geyer Rudolf, Worthmann Kirstin, Schiffer Mario, Groos Stephanie, Gerardy-Schahn Rita, Münster-Kühnel Anja K
Abstract excerpt
The role of sialylation in kidney biology is not fully understood. The synthesis of sialoglycoconjugates, which form the outermost structures of animal cells, requires CMP-sialic acid, which is a product of the nuclear enzyme CMAS. We used a knock-in strategy to create a mouse with point mutations in the canonical nuclear localization signal of CMAS, which relocated the enzyme to the cytoplasm of transfected...
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