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Article

Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 1998

Münster A K, Eckhardt M, Potvin B, Mühlenhoff M, Stanley P, Gerardy-Schahn R

Abstract excerpt

Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is species- and tissue-specific, is highly regulated during embryonic development, and changes with stages of differentiation. A prerequisite for the synthesis of sialylated glycoconjugates is the activated sugar-nucleotide cytidine...

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Identifiers

PMID: 9689047
DOI: 10.1073/pnas.95.16.9140
PMCID: PMC21305

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