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Article

Modulating the tension-time integral of the cardiac twitch prevents dilated cardiomyopathy in murine hearts.

JCI insight - 15 Oct 2020

Powers Joseph D, Kooiker Kristina B, Mason Allison B, Teitgen Abigail E, Flint Galina V, Tardiff Jil C, Schwartz Steven D, McCulloch Andrew D, Regnier Michael, Davis Jennifer, Moussavi-Harami Farid

Abstract excerpt

Dilated cardiomyopathy (DCM) is often associated with sarcomere protein mutations that confer reduced myofilament tension-generating capacity. We demonstrated that cardiac twitch tension-time integrals can be targeted and tuned to prevent DCM remodeling in hearts with contractile dysfunction. We employed a transgenic murine model of DCM caused by the D230N-tropomyosin (Tm) mutation and designed a sarcomere-based...

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Calcium Signaling
Cardiomyopathy, Dilated
Heart
Myocardial Contraction
Myocardium

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PMID: 32931484
DOI: 10.1172/jci.insight.142446
PMCID: PMC7605524

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