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Article

A straightforward guide to the sarcomeric basis of cardiomyopathies.

Heart (British Cardiac Society) - 1 Dec 2014

Lopes Luís R, Elliott Perry M

Abstract excerpt

The sarcomere is the principal contractile unit of striated muscle. Mutations in genes encoding sarcomeric proteins are responsible for a range of diseases including hypertrophic, dilated and restrictive cardiomyopathies and ventricular non-compaction. The downstream molecular pathways leading to these heterogeneous phenotypes include changes in acto-myosin cross-bridge kinetics, altered mechanosensation,...

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Identifiers

PMID: 25271316
DOI: 10.1136/heartjnl-2014-305645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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