Article
The rare Arg181Cys mutation in the μ opioid receptor can abolish opioid responses.
Acta anaesthesiologica Scandinavica - 1 Sept 2016
Skorpen F, von Hofacker S, Bjørngaard M, Skogholt A H, Dale O, Kaasa S, Klepstad P
Abstract excerpt
BACKGROUND: Genetic variability contributes to variable clinical response to opioids. This study emerged from the observation of three Norwegian patients who showed no or extraordinary poor response to very high doses of opioids. We suspected a genetic defect and applied a 'most likely candidate gene' approach to investigate this possibility. METHODS: DNA sequencing was used to search for mutations in coding...
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