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Article

Role of dimerization efficiency of transmembrane domains in activation of fibroblast growth factor receptor 3.

Journal of the American Chemical Society - 5 Jun 2013

Volynsky Pavel E, Polyansky Anton A, Fakhrutdinova Gulfia N, Bocharov Eduard V, Efremov Roman G

Abstract excerpt

Mutations in transmembrane (TM) domains of receptor tyrosine kinases are shown to cause a number of inherited diseases and cancer development. Here, we use a combined molecular modeling approach to understand molecular mechanism of effect of G380R and A391E mutations on dimerization of TM domains of human fibroblast growth factor receptor 3 (FGFR3). According to results of Monte Carlo conformational search in the...

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Source

Identifiers

PMID: 23679838
DOI: 10.1021/ja4011942

Genes

FGFR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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