Article

Mapping the free energy landscape of K-Ras4B dimerization

2025-04-26

Abstract excerpt

KRAS-4B regulates cellular proliferation and differentiation via its GTPase activity, and it is often mutated in human tumors. Deregulation of the MAPK/ERK pathway as a result of K-Ras4B mutations leads to uncontrolled proliferation, with the dimer/multimerization of K-Ras4B on the plasma membrane believed to be the initiating event for subsequent MAPK/ERK signaling. While K-Ras4B proteins are known to cluster on...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ce2f3dd7-a0b7-5736-9725-44c4a481051d
DOI: 10.1101/2025.04.22.650040

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping the free energy landscape of K-Ras4B dimerizationDOI 10.1101/2025.04.22.650040Read

Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling.Semantic proximity Read

Predicting the conformational variability of oncogenic GTP-bound G12D mutated KRas-4B proteins at zwitterionic model cell membranes.Semantic proximity Read

Long-lasting Salt Bridges Provide the Anchoring Mechanism of Oncogenic Kirsten Rat Sarcoma Proteins at Cell Membranes.Semantic proximity Read

Unveiling the KRAS Relationship between Affinity and Dynamics: A Molecular Simulations Study.Semantic proximity Read

The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.Semantic proximity Read

Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational LandscapeSemantic proximity Read

Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling.Semantic proximity Read

N-Ras forms dimers at POPC membranes.Semantic proximity Read

The plasma membrane as a competitive inhibitor and positive allosteric modulator of KRas4B signalingSemantic proximity Read

Synergy and anti-cooperativity in allostery: Molecular dynamics study of WT and oncogenic KRAS-RGL1.Semantic proximity Read

GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.Semantic proximity Read

B-Raf autoinhibition in the presence and absence of 14-3-3.Semantic proximity Read