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Article

Context-dependent effects of SOCS3 in angiotensin II-induced vascular dysfunction and hypertension in mice: mechanisms and role of bone marrow-derived cells.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2016

Li Ying, Kinzenbaw Dale A, Modrick Mary L, Pewe Lecia L, Faraci Frank M

Abstract excerpt

Carotid artery disease is a major contributor to stroke and cognitive deficits. Angiotensin II (Ang II) promotes vascular dysfunction and disease through mechanisms that include the IL-6/STAT3 pathway. Here, we investigated the importance of suppressor of cytokine signaling 3 (SOCS3) in models of Ang II-induced vascular dysfunction. We examined direct effects of Ang II on carotid arteries from SOCS3-deficient...

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Source

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Identifiers

PMID: 27106041
DOI: 10.1152/ajpheart.00204.2016
PMCID: PMC4967211

Genes

SOCS3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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