Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury.

doi:10.1161/01.RES.0000134921.50377.61

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury.

Circulation research - 23 Jul 2004

Hilfiker-Kleiner Denise, Hilfiker Andres, Fuchs Martin, Kaminski Karol, Schaefer Arnd, Schieffer Bernhard, Hillmer Anja, Schmiedl Andreas, Ding Zhaoping, Podewski Edith, Podewski Eva, Poli Valeria, Schneider Michael D, Schulz Rainer, Park Joon-Keun, Wollert Kai C, Drexler Helmut

Abstract excerpt

The transcription factor signal transducer and activator of transcription 3 (STAT3) participates in a wide variety of physiological processes and directs seemingly contradictory responses such as proliferation and apoptosis. To elucidate its role in the heart, we generated mice harboring a cardiomyocyte-restricted knockout of STAT3 using Cre/loxP-mediated recombination. STAT3-deficient mice developed reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Capillaries

Share to Coronary Vessels

Share to Culture Media, Conditioned

Share to Myocardial Ischemia

Share to Myocardial Reperfusion Injury

Share to Neovascularization, Physiologic

Share to Paracrine Communication

Source

Open in PubMed

Identifiers

PMID: 15192020
DOI: 10.1161/01.RES.0000134921.50377.61

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury.PMID 15192020Read ↗

STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident Sca-1+ cells both in vitro and in vivoSemantic proximity Read ↗

Fibroblast polarization over the myocardial infarction time continuum shifts roles from inflammation to angiogenesisSemantic proximity Read ↗

Circ-sh3rf3/GATA-4/miR-29a regulatory axis in fibroblast–myofibroblast differentiation and myocardial fibrosisSemantic proximity Read ↗

Kindlin‐3 Promotes Angiogenesis via Notch Signalling and Is Crucial for Functional Recovery Postmyocardial InfarctionSemantic proximity Read ↗

The crosstalk between STAT3 and microRNA in cardiac diseases and protectionSemantic proximity Read ↗

Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis.Semantic proximity Read ↗

Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age.Semantic proximity Read ↗

STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxiaSemantic proximity Read ↗

Sema3A promotes the resolution of cardiac inflammation after myocardial infarction.Semantic proximity Read ↗

Cooperation between VEGF and beta3 integrin during cardiac vascular development.Semantic proximity Read ↗

Emerging therapeutic targets for cardiac arrhythmias: role of STAT3 in regulating cardiac fibroblast functionSemantic proximity Read ↗

STAT3 signaling in pulmonary arterial hypertensionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.