Article
Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells.
Molecular cell - 21 Apr 2016
Pu Yingying, Zhao Zhilun, Li Yingxing, Zou Jin, Ma Qi, Zhao Yanna, Ke Yuehua, Zhu Yun, Chen Huiyi, Baker Matthew A B, Ge Hao, Sun Yujie, Xie Xiaoliang Sunney, Bai Fan
Abstract excerpt
Natural variations in gene expression provide a mechanism for multiple phenotypes to arise in an isogenic bacterial population. In particular, a sub-group termed persisters show high tolerance to antibiotics. Previously, their formation has been attributed to cell dormancy. Here we demonstrate that bacterial persisters, under β-lactam antibiotic treatment, show less cytoplasmic drug accumulation as a result of...
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