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Article

Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation.

The American journal of pathology - 1 Sept 1999

Nhieu J T, Renard C A, Wei Y, Cherqui D, Zafrani E S, Buendia M A

Abstract excerpt

Inappropriate activation of the Wnt pathway resulting from beta-catenin gene alterations has recently been implicated in the development of hepatocellular carcinoma (HCC). To explore the in vivo effects of mutated beta-catenin, HCC specimens from 32 patients carrying one or several tumors were screened for somatic mutations in exon 3 of the beta-catenin gene, and the expression and subcellular localization of...

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Identifiers

PMID: 10487827
DOI: 10.1016/s0002-9440(10)65168-1
PMCID: PMC1866892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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