Article
Guiding synovial inflammation by macrophage phenotype modulation: an in vitro study towards a therapy for osteoarthritis.
Osteoarthritis and cartilage - 1 Sept 2016
Utomo L, van Osch G J V M, Bayon Y, Verhaar J A N, Bastiaansen-Jenniskens Y M
Abstract excerpt
OBJECTIVE: The aims of this study were to modulate inflammation in synovial explants with the compounds: dexamethasone, rapamycin, bone morphogenetic protein 7 (BMP-7) and pravastatin, and to investigate the modulatory capacity of the compounds on specific macrophage phenotypes. DESIGN: Synovial explants from osteoarthritis (OA) patients were treated with 10(-6) M dexamethasone, 100 ng/mL rapamycin, 500 ng/mL...
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