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Chronic Exposure to Perfluorooctane Sulfonate Reduces Lifespan of Caenorhabditis elegans Through Insulin/IGF-1 Signaling.

Bulletin of environmental contamination and toxicology - 1 Jul 2016

Xu Tiantian, Li Ping, Wu Siyu, Li Dan, Wu Jingxuan, Raley-Susman Kathleen M, He Defu

Abstract excerpt

Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant. Although multiple adverse effects of PFOS have been demonstrated, whether PFOS can accelerate aging and affect animal longevity remains unknown. In Caenorhabditis elegans, we found that a 50 h exposure to 0.2-200 µM PFOS reduced lifespan in a concentration dependent manner. In transgenic nematodes, lifespans are affected by mutations of daf-16,...

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PMID: 27095033
DOI: 10.1007/s00128-016-1808-5

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