Article

Structure-specific variation in per- and polyfluoroalkyl substances toxicity among genetically diverse <i>Caenorhabditis elegans</i> strains

2024-06-02

Abstract excerpt

<h4>Background</h4> There are >14,500 structurally diverse per- and polyfluoroalkyl substances (PFAS). Despite knowledge that these “forever chemicals” are in 99% of humans, mechanisms of toxicity and adverse health effects are incompletely known. Furthermore, the contribution of genetic variation to PFAS susceptibility and health consequences is unknown. <h4>Objectives</h4> We determined the toxicity of a struc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 82c61678-0a76-5bba-ac38-db7324eea9a8
DOI: 10.1101/2024.05.29.596269

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure-specific variation in per- and polyfluoroalkyl substances toxicity among genetically diverse <i>Caenorhabditis elegans</i> strainsDOI 10.1101/2024.05.29.596269Read

<i>C. elegans</i> toxicant responses vary among genetically diverse individualsSemantic proximity Read

Per- and polyfluoroalkyl substances enhance Staphylococcus aureus pathogenicity and impair host immune responseSemantic proximity Read

Omics approach reveals perturbation of metabolism and phenotype in Caenorhabditis elegans triggered by perfluorinated compounds.Semantic proximity Read

Natural variation suggests candidate genes underlying <i>Caenorhabditis elegans</i> susceptibility to diverse toxicantsSemantic proximity Read

Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.Semantic proximity Read

Large-scale phenotyping in a wild rhabditid nematode and C. elegans reveals differential neurobehavioral responses to a nanoscale pollutant and temperature.Semantic proximity Read

Toxicology of carbon nanomaterials in the Caenorhabditis elegans model: current status, characterization, and perspectives for testing harmonizationSemantic proximity Read

<i>In vivo</i> quantitative high-throughput screening for drug discovery and comparative toxicologySemantic proximity Read

Application of 3Rs in Caenorhabditis elegans Research for the Identification of Health-Promoting Natural ProductsSemantic proximity Read

Brief report on differential toxicity of legacy and second-generation PFAS on dopaminergic neurons and mitochondriaSemantic proximity Read

Natural variation in <i>C. elegans</i> arsenic toxicity is explained by differences in branched chain amino acid metabolismSemantic proximity Read

Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay.Semantic proximity Read