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Article

CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer’s disease

19 Apr 2016

Abstract excerpt

BACKGROUND: CRTC1 (CREB regulated transcription coactivator 1) gene plays a role in synaptic plasticity, learning and long-term memory formation in the hippocampus. Recently, CRTC1 has been shown to be downregulated in Alzheimer's disease (AD). Nevertheless, the mechanisms underlying CRTC1 dysregulation in AD remain unclear. METHODS: To understand better the epigenetic mechanisms regulating CRTC1 expression that...

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PMID: 27094739
DOI: 10.1186/s13195-016-0183-0

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