Article
In vitro generated macrophages reflect the immunosuppressive phenotype of in vivo glioblastoma-associated macrophages.
Oncoimmunology - 31 Dec 2026
Nazzaro Matthew, Mardis Elaine R, Artomov Mykyta, Juenger Ella, Lyberger Justin, Damante Mark, Behbehani Gregory, Sarkar Susobhan, Rajappa Prajwal
Abstract excerpt
Glioblastoma (GBM) is the most common primary central nervous system tumor with a dismal prognosis and limited treatment options. Recent success utilizing immunotherapies for treating other solid tumors have been largely unsuccessful in GBM. One of the primary mechanisms of GBM immunotherapeutic resistance is because of excessive infiltration of myeloid cells that create an immunosuppressive tumor...
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