Article
Motor and nonmotor heterogeneity of LRRK2-related and idiopathic Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2016
Marras Connie, Alcalay Roy N, Caspell-Garcia Chelsea, Coffey Christopher, Chan Piu, Duda John E, Facheris Maurizio F, Fernández-Santiago Rubén, Ruíz-Martínez Javier, Mestre Tiago, Saunders-Pullman Rachel, Pont-Sunyer Claustre, Tolosa Eduardo, Waro Bjorg
Abstract excerpt
BACKGROUND: Parkinson's disease (PD) associated with LRRK2 mutations has been described as similar to idiopathic PD with minor clinical differences. No study has compared the clinical features of LRRK2-associated PD due to different mutations. The objective of this study was to compare LRRK2-associated PD due to G2019S and G2385R mutations and to compare each to idiopathic PD. METHODS: Sites within the...
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