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Article

Clinical heterogeneity of the LRRK2 G2019S mutation.

Archives of neurology - 1 Sept 2006

Papapetropoulos Spiridon, Singer Carlos, Ross Owen A, Toft Mathias, Johnson Joseph L, Farrer Matthew J, Mash Deborah C

Abstract excerpt

BACKGROUND: Several pathogenic mutations have been reported in the leucine-rich repeat kinase 2 gene (LRRK2) that cause parkinsonism. The "common" LRRK2 G2019S kinase domain substitution has been reported to account for approximately 5% of familial and 1% of sporadic Parkinson disease. OBJECTIVE: To observe the clinical heterogeneity presented by LRRK2 kinase mutation carriers. DESIGN, SETTING, AND PARTICIPANTS:...

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Identifiers

PMID: 16966501
DOI: 10.1001/archneur.63.9.1242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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