Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of genetic background on neonatal lethality of Gga2 gene-trap mice.

G3 (Bethesda, Md.) - 17 Mar 2014

Doray Balraj, Govero Jennifer, Kornfeld Stuart

Abstract excerpt

The functional redundancy of the three mammalian Golgi-localized, γ-ear-containing, ADP-ribosylation factor-binding proteins (GGAs) was addressed in a previous study. Using insertional mutagenesis, we found that Gga1 or Gga3 homozygous knockout mice were for the most part normal, whereas mice homozygous for two different Gga2 gene-trap alleles exhibited either embryonic or neonatal lethality in the C57BL/6...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to Alleles
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Mice, Knockout

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 24637350
DOI: 10.1534/g3.114.010355
PMCID: PMC4025487

Genes

GGA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of genetic background on neonatal lethality of Gga2 gene-trap mice.PMID 24637350Read ↗

A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice.Semantic proximity Read ↗

Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis.Semantic proximity Read ↗

GRASP65 controls the cis Golgi integrity in vivoSemantic proximity Read ↗

Systemic Analysis of Atg5-Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in NeuronsSemantic proximity Read ↗

Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.Semantic proximity Read ↗

Gene profiling of transgenic mice with targeted expression of activated heterotrimeric G protein alpha subunits using DNA microarray.Semantic proximity Read ↗

The unique GGA clathrin adaptor of Drosophila melanogaster is not essential.Semantic proximity Read ↗

A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency.Semantic proximity Read ↗

Generation of mice encoding a conditional null allele of Gcm2.Semantic proximity Read ↗

Mice with a homozygous deletion of the Mgat2 gene encoding UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II: a model for congenital disorder of glycosylation type IIa.Semantic proximity Read ↗

Early embryonic death of mice deficient in gamma-adaptin.Semantic proximity Read ↗

Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.