Article
Characterization of the AP-1 μ1A and μ1B adaptins in zebrafish (Danio rerio).
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2010
Zizioli Daniela, Forlanelli Elena, Guarienti Michela, Nicoli Stefania, Fanzani Alessandro, Bresciani Roberto, Borsani Giuseppe, Preti Augusto, Cotelli Franco, Schu Peter
Abstract excerpt
Protein transport between the trans-Golgi network and endosomes is mediated by transport vesicles formed by the adaptor-protein complex AP-1, consisting of the adaptins γ1, β1, μ1, σ1. Mammalia express μ1A ubiquitously and isoform μ1B in polarized epithelia. Mouse γ1 or μ1A 'knock out's revealed that AP-1 is indispensable for embryonic development. We isolated μ1A and μ1B from Danio rerio. Analysis of μ1A and μ1B...
Topics
- Adaptor Protein Complex 1
- Adaptor Protein Complex mu Subunits
- Amino Acid Sequence
- Animals
- Gene Expression Regulation, Developmental
- Gene Knockdown Techniques
- Genome
- Humans
- Mice
- Molecular Sequence Data
- Morphogenesis
- Phenotype