Article
Early embryonic death of mice deficient in gamma-adaptin.
The Journal of biological chemistry - 26 Feb 1999
Zizioli D, Meyer C, Guhde G, Saftig P, von Figura K, Schu P
Abstract excerpt
Intracellular protein transport and sorting by vesicles in the secretory and endocytic pathways requires the formation of a protein coat on the membrane. The heterotetrameric adaptor protein complex 1 (AP-1) promotes the formation of clathrin-coated vesicles at the trans-Golgi network. AP-1 interacts with various sorting signals in the cytoplasmic tails of cargo molecules, thus indicating a function in protein...
Topics
- Adaptor Protein Complex gamma Subunits
- Animals
- Fetal Death
- Genes, Lethal
- Heterozygote
- Membrane Proteins
- Mice
- Mutagenesis, Site-Directed
- Phenotype