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Article

Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Mar 2017

Chang Jiun C, Sebastian Aimy, Murugesh Deepa K, Hatsell Sarah, Economides Aris N, Christiansen Blaine A, Loots Gabriela G

Abstract excerpt

Joint injury causes post-traumatic osteoarthritis (PTOA). About ∼50% of patients rupturing their anterior cruciate ligament (ACL) will develop PTOA within 1-2 decades of the injury, yet the mechanisms responsible for the development of PTOA after joint injury are not well understood. In this study, we examined whole joint gene expression by RNA sequencing (RNAseq) at 1 day, 1-, 6-, and 12 weeks post injury, in a...

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Source

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Identifiers

PMID: 27088242
DOI: 10.1002/jor.23263
PMCID: PMC5363336

Genes

COMP
MMP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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