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Article

Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis models

24 Sept 2024

Abstract excerpt

Animal models of post-traumatic osteoarthritis (PTOA) recapitulate the pathological changes observed in human PTOA. Here, skeletally mature C57Bl6 mice were subjected to either rapid-onset non-surgical mechanical rupture of the anterior cruciate ligament (ACL) or to surgical destabilisation of the medial meniscus (DMM). Transcriptome profiling of micro-dissected cartilage at day 7 or day 42 following ACL or DMM...

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PMID: 39314058
DOI: 10.1242/dmm.050583

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