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Global analyses of gene expression in early experimental osteoarthritis

25 May 2007

Abstract excerpt

OBJECTIVE: To analyze genome-wide changes in chondrocyte gene expression in a surgically induced model of early osteoarthritis (OA) in rats, to assess the similarity of this model to human OA, and to identify genes and mechanisms leading to OA pathogenesis. METHODS: OA was surgically induced in 5 rats by anterior cruciate ligament transection and partial medial meniscectomy. Sham surgery was performed in 5...

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Connective Tissue Growth Factor Research
Knee injuries and reconstruction techniques
Osteoarthritis Treatment and Mechanisms

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PMID: 17530714
DOI: 10.1002/art.22711

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