Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model

5 Apr 2016

Abstract excerpt

BACKGROUND: Tetherin is an intrinsic anti-viral factor impairing the release of nascent HIV-1 particles from infected cells. Vpu, an HIV-1 accessory protein, antagonizes the anti-viral action of tetherin. Although previous studies using in vitro cell culture systems have revealed the molecular mechanisms of the anti-viral action of tetherin and the antagonizing action of Vpu against tetherin, it still remains...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27086687
DOI: 10.1186/s12977-016-0252-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse modelPMID 27086687Read ↗

Modulation of HIV-1-host interaction: role of the Vpu accessory proteinSemantic proximity Read ↗

Vpu Augments the Initial Burst Phase of HIV-1 Propagation and Downregulates BST2 and CD4 in Humanized MiceSemantic proximity Read ↗

Species-Specific Activity of HIV-1 Vpu and Positive Selection of Tetherin Transmembrane Domain VariantsSemantic proximity Read ↗

Small but Highly Versatile: The Viral Accessory Protein VpuSemantic proximity Read ↗

Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In VivoSemantic proximity Read ↗

Determinants of Tetherin Antagonism in the Transmembrane Domain of the Human Immunodeficiency Virus Type 1 Vpu ProteinSemantic proximity Read ↗

Tetherin/BST-2: Restriction Factor or Immunomodulator?Semantic proximity Read ↗

Simian immunodeficiency virus envelope glycoprotein counteracts tetherin/BST-2/CD317 by intracellular sequestrationSemantic proximity Read ↗

Transmembrane interactions of HIV-1 Vpu and tetherin.Semantic proximity Read ↗

Estimating biologically relevant parameters under uncertainty for experimental within-host murine West Nile virus infectionSemantic proximity Read ↗

Mutation of a single residue renders human tetherin resistant to HIV-1 Vpu-mediated depletion.Semantic proximity Read ↗

Tetherin Can Restrict Cell-Free and Cell-Cell Transmission of HIV from Primary Macrophages to T CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.