Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination.

Nucleic acids research - 8 Jul 2016

Onyango David O, Howard Sean M, Neherin Kashfia, Yanez Diana A, Stark Jeremy M

Abstract excerpt

We examined the influence of the tetratricopeptide repeat factor XAB2 on chromosomal break repair, and found that XAB2 promotes end resection that generates the 3' ssDNA intermediate for homologous recombination (HR). Namely, XAB2 is important for chromosomal double-strand break (DSB) repair via two pathways of HR that require end resection as an intermediate step, end resection of camptothecin (Cpt)-induced DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Camptothecin
Share to Chromosome Breakage
Share to DNA End-Joining Repair

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Homologous Recombination

Share to Rad51 Recombinase

Share to Radiation, Ionizing

Share to Recombinational DNA Repair

Share to RNA Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 27084940
DOI: 10.1093/nar/gkw275
PMCID: PMC4937314

Genes

XAB2
BRCA1
ISY1
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination.PMID 27084940Read ↗

RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1.Semantic proximity Read ↗

BRCA1-Dependent and Independent Recruitment of PALB2–BRCA2–RAD51 in the DNA Damage Response and CancerSemantic proximity Read ↗

Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forksSemantic proximity Read ↗

DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signalingSemantic proximity Read ↗

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.Semantic proximity Read ↗

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break RepairSemantic proximity Read ↗

The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.Semantic proximity Read ↗

The human HELLS chromatin remodelling protein promotes end resection to facilitate homologous recombination and contributes to DSB repair within heterochromatinSemantic proximity Read ↗

Mechanism of MRX inhibition by Rif2 at telomeres.Semantic proximity Read ↗

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners.Semantic proximity Read ↗

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylationSemantic proximity Read ↗

Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.