Article
Biotinylation: a novel posttranslational modification linking cell autonomous circadian clocks with metabolism.
American journal of physiology. Heart and circulatory physiology - 1 Jun 2016
He Lan, Hamm J Austin, Reddy Alex, Sams David, Peliciari-Garcia Rodrigo A, McGinnis Graham R, Bailey Shannon M, Chow Chi-Wing, Rowe Glenn C, Chatham John C, Young Martin E
Abstract excerpt
Circadian clocks are critical modulators of metabolism. However, mechanistic links between cell autonomous clocks and metabolic processes remain largely unknown. Here, we report that expression of the biotin transporter slc5a6 gene is decreased in hearts of two distinct genetic mouse models of cardiomyocyte-specific circadian clock disruption [i.e., cardiomyocyte-specific CLOCK mutant (CCM) and...
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