Article

A <i>Slc5a6</i> Deficient Mouse Model Reveals a Metabolically Driven Dilated Cardiomyopathy with Therapeutic Potential for Vitamin-Based Intervention

2025-06-09

Abstract excerpt

<h4>Background and Aims</h4> The sodium-dependent multivitamin transporter, encoded by SLC5A6 , mediates cellular uptake of the vitamins, biotin and pantothenic acid, both of which are essential cofactors for energy metabolism. Here, we report two families with SLC5A6 mutations presenting with early-onset dilated cardiomyopathy (DCM). To investigate the link between vitamin deficiency and DCM, we generated a no...

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Literature Corpus work: 82bfe45d-8c96-57c2-924f-b23c682db027
DOI: 10.1101/2025.06.06.658273

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A <i>Slc5a6</i> Deficient Mouse Model Reveals a Metabolically Driven Dilated Cardiomyopathy with Therapeutic Potential for Vitamin-Based InterventionDOI 10.1101/2025.06.06.658273Read

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