Article
Determining the frequency of pathogenic germline variants from exome sequencing in patients with castrate-resistant prostate cancer.
BMJ open - 15 Apr 2016
Hart Steven N, Ellingson Marissa S, Schahl Kim, Vedell Peter T, Carlson Rachel E, Sinnwell Jason P, Barman Poulami, Sicotte Hugues, Eckel-Passow Jeanette E, Wang Liguo, Kalari Krishna R, Qin Rui, Kruisselbrink Teresa M, Jimenez Rafael E, Bryce Alan H, Tan Winston, Weinshilboum Richard, Wang Liewei, Kohli Manish
Abstract excerpt
OBJECTIVES: To determine the frequency of pathogenic inherited mutations in 157 select genes from patients with metastatic castrate-resistant prostate cancer (mCRPC). DESIGN: Observational. SETTING: Multisite US-based cohort. PARTICIPANTS: Seventy-one adult male patients with histological confirmation of prostate cancer, and had progressive disease while on androgen deprivation therapy. RESULTS: Twelve patients...
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