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Article

Targeting Sirtuin-1 prolongs murine renal allograft survival and function.

Kidney international - 1 May 2016

Levine Matthew H, Wang Zhonglin, Xiao Haiyan, Jiao Jing, Wang Liqing, Bhatti Tricia R, Hancock Wayne W, Beier Ulf H

Abstract excerpt

Current immunosuppressive medications used after transplantation have significant toxicities. Foxp3(+) T-regulatory cells can prevent allograft rejection without compromising protective host immunity. Interestingly, inhibiting the class III histone/protein deacetylase Sirtuin-1 can augment Foxp3(+) T-regulatory suppressive function through increasing Foxp3 acetylation. Here we determined whether Sirtuin-1...

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Identifiers

PMID: 27083279
DOI: 10.1016/j.kint.2015.12.051
PMCID: PMC4834143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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